Article
Phenotypic alterations in circulating monocytes induced by open heart surgery using heparinized and nonheparinized cardiopulmonary bypass systems.
Artificial organs - 1 Oct 1997
Ljunghusen O, Cederholm I, Lundahl J, Nilsson B, Olin C, Sjögren F, Stendahl O
Abstract excerpt
In this study of 31 patients with coronary bypass surgery, we used flow cytometry to compare heparin-coated and noncoated cardiopulmonary bypass systems on leukocyte activation. We found significant differences between the groups during bypass, with activation of the complement system, measured as elevated levels of C3a desArg, upregulation of granulocyte beta2 integrin (CD11b), and a loss of circulating...
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