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HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information.

Nucleic acids research - 2 Jul 2018

Sumbalova Lenka, Stourac Jan, Martinek Tomas, Bednar David, Damborsky Jiri

Abstract excerpt

HotSpot Wizard is a web server used for the automated identification of hotspots in semi-rational protein design to give improved protein stability, catalytic activity, substrate specificity and enantioselectivity. Since there are three orders of magnitude fewer protein structures than sequences in bioinformatic databases, the major limitation to the usability of previous versions was the requirement for the...

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Identifiers

PMID: 29796670
DOI: 10.1093/nar/gky417
PMCID: PMC6030891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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