Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abrogation of Marek's disease virus replication using CRISPR/Cas9.

Scientific reports - 2 Jul 2020

Hagag Ibrahim T, Wight Darren J, Bartsch Denise, Sid Hicham, Jordan Ingo, Bertzbach Luca D, Schusser Benjamin, Kaufer Benedikt B

Abstract excerpt

Marek's disease virus (MDV) is a highly cell-associated alphaherpesvirus that causes deadly lymphomas in chickens. While vaccination protects against clinical symptoms, MDV field strains can still circulate in vaccinated flocks and continuously evolve towards greater virulence. MDV vaccines do not provide sterilizing immunity, allowing the virus to overcome vaccine protection, and has increased the need for more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chick Embryo
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Viral

Share to Marek Disease

Share to Proof of Concept Study

Share to RNA, Guide, CRISPR-Cas Systems

Share to Specific Pathogen-Free Organisms

Source

Open in PubMed Open full text

Identifiers

PMID: 32616820
DOI: 10.1038/s41598-020-67951-1
PMCID: PMC7331644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abrogation of Marek's disease virus replication using CRISPR/Cas9.PMID 32616820Read ↗

Application of CRISPR/Cas9 Gene Editing System on MDV-1 Genome for the Study of Gene FunctionSemantic proximity Read ↗

Application of CRISPR/Cas9 in Understanding Avian Viruses and Developing Poultry VaccinesSemantic proximity Read ↗

Latest Advances of Virology Research Using CRISPR/Cas9-Based Gene-Editing Technology and Its Application to Vaccine DevelopmentSemantic proximity Read ↗

Recombinant Marek’s disease virus expressing VP1 and VP2 proteins provides robust immune protection against chicken infectious anemia virusSemantic proximity Read ↗

In Vivo Inhibition of Marek’s Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4Semantic proximity Read ↗

Application of CRISPR-Cas9 Editing for Virus Engineering and the Development of Recombinant Viral VaccinesSemantic proximity Read ↗

CRISPR/Cas9-Based Antiviral Strategy: Current Status and the Potential ChallengeSemantic proximity Read ↗

Latest Insights into Marek’s Disease Virus Pathogenesis and TumorigenesisSemantic proximity Read ↗

The Application of CRISPR/Cas Systems for Antiviral TherapySemantic proximity Read ↗

Immunity and Viral Infections: Modulating Antiviral Response via CRISPR–Cas SystemsSemantic proximity Read ↗

Inhibition of DNA-Sensing Pathway by Marek's Disease Virus VP23 Protein through Suppression of Interferon Regulatory Factor 7 ActivationSemantic proximity Read ↗

Immunity to Marek's disease: where are we now?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.