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Article

Depicting Changes in Tumor Biology in Response to Cetuximab Monotherapy or Combination Therapy by Apoptosis and Proliferation Imaging Using 18F-ICMT-11 and 18F-FLT PET.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Oct 2018

Heinzmann Kathrin, Nguyen Quang-Dé, Honess Davina, Smith Donna-Michelle, Stribbling Stephen, Brickute Diana, Barnes Chris, Griffiths John, Aboagye Eric

Abstract excerpt

Imaging biomarkers must demonstrate their value in monitoring treatment. Two PET tracers, the caspase-3/7-specific isatin-5-sulfonamide 18F-ICMT-11 (18F-(S)-1-((1-(2-fluoroethyl)-1H-[1,2,3]-triazol-4-yl)methyl)-5-(2(2,4-difluoro-phenoxymethyl)-pyrrolidine-1-sulfonyl)isatin) and 18F-FLT (3'-deoxy-3'-18F-fluorothymidine), were used to detect early treatment-induced changes in tumor biology and determine whether any...

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Identifiers

PMID: 29794225
DOI: 10.2967/jnumed.118.209304
PMCID: PMC6167530

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ICMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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