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Article

Infantile Onset Intractable Inflammatory Bowel Disease Due to Novel Heterozygous Mutations in TNFAIP3 (A20).

Inflammatory bowel diseases - 29 Nov 2018

Zheng Cuifang, Huang Ying, Ye Ziqing, Wang Yuhuan, Tang Zifei, Lu Junping, Wu Jie, Zhou Ying, Wang Lin, Huang Zhiheng, Yang Haowei, Xue Aijuan

Abstract excerpt

Background: Mutations in tumor necrosis factor alpha-induced protein 3 (TNFAIP3), a key player in the negative feedback regulation of nuclear factor-κB signaling, have recently been recognized as leading to early onset autoinflammatory and autoimmune syndrome. Here, we have reported the phenotypes of 3 infantile onset intractable inflammatory bowel disease (IBD) patients with TNFAIP3 mutations and reviewed...

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Source

Identifiers

PMID: 29788367
DOI: 10.1093/ibd/izy165

Genes

TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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