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Article

Five children with haploinsufficiency of A20 caused by heterozygous mutations in the TNFAIP3 gene.

Frontiers in immunology - 1 Jan 2026

Yao Hengpan, Liu Yijing, Dong MengJun, Yang Kairui, Yu Zhidan, Zhou Fang

Abstract excerpt

Objectives: Children with A20 haploinsufficiency, resulting from heterozygous variants in the TNFAIP3 gene, are increasingly being identified. However, their diagnosis and treatment remain challenging and are not yet fully optimized. The clinical, genetic characteristics and treatment methods of five children with HA20 from different families were collected from Henan Children's Hospital between April 2019 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41890736
DOI: 10.3389/fimmu.2026.1738656
PMCID: PMC13013434

Genes

TNFAIP3
CRP
MMACHC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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