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Article

Candidate gene analysis in the São Paulo Epidemiologic Sleep Study (EPISONO) shows an association of variant in PDE4D and sleepiness.

Sleep medicine - 1 Jul 2018

Pak Victoria M, Mazzotti Diego R, Keenan Brendan T, Hirotsu Camila, Gehrman Philip, Bittencourt Lia, Pack Allan I, Tufik Sergio

Abstract excerpt

INTRODUCTION: Sleepiness and cardiovascular disease share common molecular pathways; thus, genetic risk factors for sleepiness may also predict cardiovascular disease risk. This study explored the associations between subjective sleepiness and single-nucleotide polymorphisms (SNPs) in candidate genes within oxidative stress, inflammatory, and neuronal pathways, which may contribute to sleepiness and downstream...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29783161
DOI: 10.1016/j.sleep.2017.12.010

Genes

PDE4D
CYBA
CYBB
NCF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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