Article
New approach to accurate interpretation of sickle cell disease newborn screening by applying multiple of median cutoffs and ratios.
Pediatric blood & cancer - 1 Sept 2018
Allaf Bichr, Patin Franck, Elion Jacques, Couque Nathalie
Abstract excerpt
BACKGROUND: The main goal of newborn screening (NBS) for sickle cell disease (SCD) is to detect affected neonates so that specific preventive care can be implemented. High-performance liquid chromatography (HPLC) used for NBS has high sensitivity and specificity, but we lack guidelines for quantitative hemoglobin (Hb) fraction interpretation. The purpose of this study was to determine cutoff values to standardize...
Topics
- Anemia, Sickle Cell
- Artifacts
- Blood Transfusion
- Chromatography, High Pressure Liquid
- Female
- France
- Genotype
- Hemoglobin A
- Hemoglobin C
- Hemoglobin, Sickle
- Hemoglobinometry
- Humans
- Infant, Newborn
- Male
- Neonatal Screening
- Retrospective Studies
- Sensitivity and Specificity
- beta-Thalassemia