Article

Identification of microRNAs with therapeutic potentials on prostate cancer drug targets: In-silico prediction and In-vitro validation

2022-11-30

Abstract excerpt

Developing novel strategies for cancer treatment is essential in modern medicine. MiRNAs are master regulators of gene expression and act as control nodes or hubs in regulatory networks. Thus, we hypothesized that miRNAs could be an appropriate and novel therapeutic tool simultaneously targeting a candidate gene set. We defined a set of druggable genes with approved clinical outcomes in prostate cancer by a litera...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54600c7d-5a92-53c8-8c7f-928eb4f9d94a
DOI: 10.21203/rs.3.rs-2317689/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of microRNAs with therapeutic potentials on prostate cancer drug targets: In-silico prediction and In-vitro validationDOI 10.21203/rs.3.rs-2317689/v1Read

Bioinformatics and system biology approaches for identifying potential therapeutic targets for prostate cancerSemantic proximity Read

Identification of the Key MicroRNAs and the miRNA-mRNA Regulatory Pathways in Prostate Cancer by Bioinformatics MethodsSemantic proximity Read

Identification of Potential Key Genes in Prostate Cancer with Gene Expression, Pivotal Pathways and Regulatory Networks Analysis Using Integrated Bioinformatics MethodsSemantic proximity Read

Integrative Analysis of four miRNA prognostic signatures of prostate cancerSemantic proximity Read

Non-Coding RNA Biomarkers in Prostate Cancer: Evidence Mapping and in Silico CharacterizationSemantic proximity Read

Therapeutic Potential of miRNAs in Prostate Cancer: From Mechanisms to Targeted Therapy and Clinical ApplicationsSemantic proximity Read

The value of a group of serum miRNAs in screening prostate cancerSemantic proximity Read

Identification of miRNAs biomarkers for prostate cancer in serum and tissue based on bioinformatic analysis and experimental validationSemantic proximity Read

Construction and analysis of mRNA, miRNA, lncRNA, and TF regulatory networks reveal the key genes associated with prostate cancerSemantic proximity Read

Identification of miR-30b-3p and miR-30d-5p as direct regulators of androgen receptor signaling in prostate cancer by complementary functional microRNA library screeningSemantic proximity Read

Screening key microRNAs for castration-resistant prostate cancer based on miRNA/mRNA functional synergistic networkSemantic proximity Read

Novel diagnostic and prognostic classifiers for prostate cancer identified by genome-wide microRNA profilingSemantic proximity Read