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Article

A computational study of hedgehog signalling involved in basal cell carcinoma reveals the potential and limitation of combination therapy.

BMC cancer - 18 May 2018

Buetti-Dinh Antoine, Jensen Rebecca, Friedman Ran

Abstract excerpt

BACKGROUND: The smoothened (SMO) receptor is an essential component of the Sonic hedgehog (SHH) signalling, which is associated with the development of skin basal cell carcinoma (BCC). SMO inhibitors are indicated for BCC patients when surgical treatment or radiation therapy are not possible. Unfortunately, SMO inhibitors are not always well tolerated due to severe side effects, and their therapeutical success is...

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Identifiers

PMID: 29776351
DOI: 10.1186/s12885-018-4451-1
PMCID: PMC5960207

Genes

SMO
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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