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X-Linked Dilated Cardiomyopathy: A Cardiospecific Phenotype of Dystrophinopathy

9 Jun 2015

Abstract excerpt

X-linked dilated cardiomyopathy (XLDCM) is a distinct phenotype of dystrophinopathy characterized by preferential cardiac involvement without any overt skeletal myopathy. XLDCM is caused by mutations of the Duchenne muscular dystrophy (DMD) gene and results in lethal heart failure in individuals between 10 and 20 years. Patients with Becker muscular dystrophy, an allelic disorder, have a milder phenotype of...

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PMID: 26066469
DOI: 10.3390/ph8020303

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