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Article

The Sp1/FOXC1/HOTTIP/LATS2/YAP/β-catenin cascade promotes malignant and metastatic progression of osteosarcoma.

Molecular oncology - 1 Oct 2020

Liu Ke, Ni Jiang-Dong, Li Wen-Zhao, Pan Bai-Qi, Yang Yu-Ting, Xia Qin, Huang Jun

Abstract excerpt

The prognosis for osteosarcoma (OS) is dismal due to the aggressive tumor growth and high incidence of metastasis. The long noncoding RNA human homeobox A transcript at the distal tip (HOTTIP) and the transcription factor forkhead box C1 (FOXC1) present oncogenic activities in OS. Here, we aimed at gaining insights into the underlying mechanisms and their crosstalk. The expression of FOXC1 and HOTTIP in OS...

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Source

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Identifiers

PMID: 32634265
DOI: 10.1002/1878-0261.12760
PMCID: PMC7530777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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