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Article

Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy.

PloS one - 1 Jan 2020

Onusko Evan, McDermott Michael R, Robbins Nathan, Liu Guansheng, Kranias Evangelia G, Rubinstein Jack, Koch Sheryl E

Abstract excerpt

Probenecid has been used for decades in the treatment of gout but recently has also been found to improve outcomes in patients with heart failure via stimulation of the transient receptor potential vanilloid 2 (TRPV2) channel in cardiomyocytes. This study tested the use of probenecid on a novel mouse model of peripartum cardiomyopathy (PPCM) as a potential treatment option. A human mutation of the human heat...

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Share to Apoptosis
Share to Calcium Channels
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Echocardiography

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Share to Pregnancy Complications, Cardiovascular

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Source

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Identifiers

PMID: 32218573
DOI: 10.1371/journal.pone.0230386
PMCID: PMC7100971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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