Anti-Epidermal Growth Factor Vaccine Antibodies Enhance the Efficacy of Tyrosine Kinase Inhibitors and Delay the Emergence of Resistance in EGFR Mutant Lung Cancer Cells.

doi:10.1016/j.jtho.2018.04.030

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Article

Anti-Epidermal Growth Factor Vaccine Antibodies Enhance the Efficacy of Tyrosine Kinase Inhibitors and Delay the Emergence of Resistance in EGFR Mutant Lung Cancer Cells.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2018

Codony-Servat Jordi, García-Roman Silvia, Molina-Vila Miguel Ángel, Bertran-Alamillo Jordi, Giménez-Capitán Ana, Viteri Santiago, Cardona Andrés F, D'Hondt Erik, Karachaliou Niki, Rosell Rafael

Abstract excerpt

INTRODUCTION: Mutations in EGFR correlate with impaired response to immune checkpoint inhibitors and the development of novel immunotherapeutic approaches for EGFR mutant NSCLC is of particular interest. Immunization against epidermal growth factor (EGF) has shown efficacy in a phase III trial including unselected NSCLC patients, but little was known about the mechanisms involved in the effects of the anti-EGF...

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PMID: 29751136
DOI: 10.1016/j.jtho.2018.04.030

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EGFR
EGF
AXL
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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