Article
The amino acid selected for generating mutant TbpB antigens defective in binding transferrin can compromise the in vivo protective capacity.
Scientific reports - 9 May 2018
Guizzo João Antônio, Chaudhuri Somshukla, Prigol Simone Ramos, Yu Rong-Hua, Dazzi Cláudia Cerutti, Balbinott Natalia, Frandoloso Gabriela Paraboni, Kreutz Luiz Carlos, Frandoloso Rafael, Schryvers Anthony Bernard
Abstract excerpt
Haemophilus parasuis is the causative agent of the Glässer's disease (GD), one of the most important bacterial diseases that affect young pigs worldwide. GD prevention based on vaccination is a major concern due to the limited cross-protection conferred by the inactivated whole cell vaccines used currently. In this study, vaccines based on two mutant recombinant proteins derived from transferrin binding protein B...
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