Article
Immunization of aged pigs with attenuated pseudorabies virus vaccine combined with CpG oligodeoxynucleotide restores defective Th1 immune responses.
PloS one - 1 Jan 2013
Ming Feiping, Yang Jun, Chu Pinpin, Ma Miaopeng, Shi Juqing, Cai Haiming, Huang Chaoyuan, Li Huazhou, Jiang Zhenggu, Wang Houguang, Wang Weifang, Zhang Shuiqing, Zhang Linghua
Abstract excerpt
BACKGROUND AND AIMS: Attempts to immunize aged subjects often result in the failure to elicit a protective immune response. Murine model studies have shown that oligonucleotides containing CpG motifs (CpG ODN) can stimulate immune system in aged mice as effectively as in young mice. Since many physiological and pathophysiological data of pigs can be transferred to humans, research in pigs is important to confirm...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.