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Article

Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice.

Cell reports - 8 May 2018

Jorge-Torres Olga C, Szczesna Karolina, Roa Laura, Casal Carme, Gonzalez-Somermeyer Louisa, Soler Marta, Velasco Cecilia D, Martínez-San Segundo Pablo, Petazzi Paolo, Sáez Mauricio A, Delgado-Morales Raúl, Fourcade Stephane, Pujol Aurora, Huertas Dori, Llobet Artur, Guil Sonia, Esteller Manel

Abstract excerpt

Rett syndrome (RTT) is the second leading cause of mental impairment in girls and is currently untreatable. RTT is caused, in more than 95% of cases, by loss-of-function mutations in the methyl CpG-binding protein 2 gene (MeCP2). We propose here a molecular target involved in RTT: the glycogen synthase kinase-3b (Gsk3b) pathway. Gsk3b activity is deregulated in Mecp2-knockout (KO) mice models, and SB216763, a...

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Identifiers

PMID: 29742424
DOI: 10.1016/j.celrep.2018.04.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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