Molecular alterations associated with chronic exposure to cigarette smoke and chewing tobacco in normal oral keratinocytes.

doi:10.1080/15384047.2018.1470724

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Article

Molecular alterations associated with chronic exposure to cigarette smoke and chewing tobacco in normal oral keratinocytes.

Cancer biology & therapy - 1 Jan 2018

Rajagopalan Pavithra, Patel Krishna, Jain Ankit P, Nanjappa Vishalakshi, Datta Keshava K, Subbannayya Tejaswini, Mangalaparthi Kiran K, Kumari Anjali, Manoharan Malini, Coral Karunakaran, Murugan Sakthivel, Nair Bipin, Prasad T S Keshava, Mathur Premendu P, Gupta Ravi, Gupta Rohit, Khanna-Gupta Arati, Califano Joseph, Sidransky David, Gowda Harsha, Chatterjee Aditi

Abstract excerpt

Tobacco usage is a known risk factor associated with development of oral cancer. It is mainly consumed in two different forms (smoking and chewing) that vary in their composition and methods of intake. Despite being the leading cause of oral cancer, molecular alterations induced by tobacco are poorly understood. We therefore sought to investigate the adverse effects of cigarette smoke/chewing tobacco exposure in...

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Identifiers

PMID: 29723088
DOI: 10.1080/15384047.2018.1470724
PMCID: PMC6154853

Genes

EGFR
MAPK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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