Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gamma-aminobutyric acid (GABA) receptors genes polymorphisms and risk for restless legs syndrome.

The pharmacogenomics journal - 1 Jul 2018

Jiménez-Jiménez Félix Javier, Esguevillas Gara, Alonso-Navarro Hortensia, Zurdo Martín, Turpín-Fenoll Laura, Millán-Pascual Jorge, Adeva-Bartolomé Teresa, Cubo Esther, Navacerrada Francisco, Amo Gemma, Rojo-Sebastián Ana, Rubio Lluisa, Díez-Fairén Mónica, Pastor Pau, Calleja Marisol, Plaza-Nieto José Francisco, Pilo-de-la-Fuente Belén, Arroyo-Solera Margarita, García-Albea Esteban, Agúndez José A G, García-Martín Elena

Abstract excerpt

The possible role of gammaaminobutyric acid (GABA) in the pathophysiology of restless legs syndrome (RLS) is suggested by the symptomatic improvement achieved with GABAergic drugs. Thalamic GABA levels have shown positive correlation with periodic limb movements indices and with RLS severity. We tried to investigate the possible association between the most common single nucleotide polymorphisms (SNPs) in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles

Share to Genetic Association Studies

Share to Receptors, GABA

Share to Receptors, GABA-A

Share to Restless Legs Syndrome

Share to Risk Factors

Source

Identifiers

PMID: 29720720
DOI: 10.1038/s41397-018-0023-7

Genes

GABRA4
GABRR3
GABRE
GABRQ
GABRR1
GABRR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gamma-aminobutyric acid (GABA) receptors genes polymorphisms and risk for restless legs syndrome.PMID 29720720Read ↗

Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor.Semantic proximity Read ↗

Gamma-Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine.Semantic proximity Read ↗

Gamma-aminobutyric acid GABRA4, GABRE, and GABRQ receptor polymorphisms and risk for essential tremor.Semantic proximity Read ↗

Genetics of restless legs syndrome.Semantic proximity Read ↗

Genetics in restless legs syndrome.Semantic proximity Read ↗

Gamma-aminobutyric acid (GABA) receptors GABRA4, GABRE, and GABRQ gene polymorphisms and risk for migraine.Semantic proximity Read ↗

The solute carrier family 1 (glial high affinity glutamate transporter), member 2 gene, SLC1A2, rs3794087 variant and assessment risk for restless legs syndrome.Semantic proximity Read ↗

Serum vitamin D, vitamin D receptor and binding protein genes polymorphisms in restless legs syndrome.Semantic proximity Read ↗

Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility.Semantic proximity Read ↗

Restless legs syndrome.Semantic proximity Read ↗

[Pathophysiology of restless legs syndrome].Semantic proximity Read ↗

Neuronal nitric oxide synthase (nNOS, NOS1) rs693534 and rs7977109 variants and risk for restless legs syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.