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Article

Kynurenine Pathway in Autism Spectrum Disorders in Children

1 Jan 2017

Abstract excerpt

BACKGROUND: There is increasing evidence that altered immune responses play a role in the pathogenesis of autism spectrum disorders (ASD), together with dysfunction of the serotonergic and glutamatergic systems. Since the kynurenine (KYN) pathway that degrades tryptophan (TRP) is activated in various neuroinflammatory states, we aimed to determine whether this pathway is activated in ASD. METHODS: Sixty-five...

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PMID: 29694960
DOI: 10.1159/000488157

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