Article
Kynurenine pathway and autism spectrum phenotypes: an investigation among adults with autism spectrum disorder and their first-degree relatives.
CNS spectrums - 1 Jun 2023
Carpita Barbara, Nardi Benedetta, Palego Lionella, Cremone Ivan M, Massimetti Gabriele, Carmassi Claudia, Betti Laura, Giannaccini Gino, Dell'Osso Liliana
Abstract excerpt
BACKGROUND: Increasing literature highlighted alterations of tryptophan (TRP) metabolism and kynurenine (KYN) pathway in children with autism spectrum disorder (ASD). However, no study specifically focused on adult samples. Meanwhile, several authors stressed the relevance of investigating neurobiological correlates of adult forms of ASD and of those subthreshold ASD manifestations frequently found in relatives...
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