Genomic Response to Vitamin D Supplementation in the Setting of a Randomized, Placebo-Controlled Trial

Abstract excerpt

BACKGROUND: Vitamin D deficiency has been associated with multiple diseases, but the causal relevance and underlying processes are not fully understood. Elucidating the mechanisms of action of drug treatments in humans is challenging, but application of functional genomic approaches in randomized trials may afford an opportunity to systematically assess molecular responses. METHODS: 4000 IU, 2000 IU or placebo...

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