Article
Monotypic low-level HIV viremias during antiretroviral therapy are associated with disproportionate production of X4 virions and systemic immune activation.
AIDS (London, England) - 17 Jul 2018
Bull Marta E, Mitchell Caroline, Soria Jaime, Styrchak Sheila, Williams-Wietzikoski Corey, Legard Jillian, McKernan-Mullin Jennifer, Kraft Kelli, Onchiri Frankline, Stern Joshua, Holte Sarah, Ryan Kevin J, Acosta Edward P, La Rosa Alberto, Coombs Robert W, Ticona Eduardo, Frenkel Lisa M
Abstract excerpt
OBJECTIVE: During effective antiretroviral therapy (ART), low-level plasma viremias (LLV) (HIV RNA >30-1000 copies/ml) can be detected intermittently. We hypothesized that systemic inflammation is associated with LLV either as the cause or result of the production of virions from clonally expanded cells. METHODS: Prospective cohort study of HIV-infected ART-naive Peruvians enrolled prior to ART and followed for 2...
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