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Germ cell depletion from mammalian ovary: possible involvement of apoptosis and autophagy

23 Apr 2018

Abstract excerpt

Mammalian ovary contains millions of germ cells during embryonic life but only few of them are culminated into oocytes that achieve meiotic competency just prior to ovulation. The majority of germ cells are depleted from ovary through several pathways. Follicular atresia is one of the major events that eliminate germ cells from ovary by engaging apoptotic as well as non-apoptotic pathways of programmed cell...

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PMID: 29681242
DOI: 10.1186/s12929-018-0438-0

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