Microsatellite instability in prostate cancer by PCR or next-generation sequencing

doi:10.1186/s40425-018-0341-y

Article

Microsatellite instability in prostate cancer by PCR or next-generation sequencing

17 Apr 2018

Abstract excerpt

BACKGROUND: Microsatellite instability (MSI) is now being used as a sole biomarker to guide immunotherapy treatment for men with advanced prostate cancer. Yet current molecular diagnostic tests for MSI have not been evaluated for use in prostate cancer. METHODS: We evaluated two next-generation sequencing (NGS) MSI-detection methods, MSIplus (18 markers) and MSI by Large Panel NGS (> 60 markers), and compared the...

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