Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reversing Multidrug Resistance by Multiplexed Gene Silencing for Enhanced Breast Cancer Chemotherapy

17 Apr 2018

Abstract excerpt

Multidrug resistance (MDR), as one of the main problems in clinical breast cancer chemotherapy, is closely related with the over expression of drug efflux transporter P-glycoprotein (P-gp). In this study, a novel drug-loaded nanosystem was developed for inhibiting the P-gp expression and reversing MDR by multiplexed gene silencing, which composes of graphene oxide (GO) modified with two molecular beacons (MBs)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to RNA Interference and Gene Delivery

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29663807
DOI: 10.1021/acsami.8b02800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reversing Multidrug Resistance by Multiplexed Gene Silencing for Enhanced Breast Cancer ChemotherapyPMID 29663807Read ↗

DNA Nanoflower Enables Controlled Co-Delivery of Antisense Oligodeoxynucleotide and Doxorubicin for Anti-breast Cancer TreatmentSemantic proximity Read ↗

Nanomedicine Strategies to Overcome Multi-Drug Resistance in Cancer: Innovations in Targeted Delivery, Tumor Microenvironment Modulation and Synergistic TherapiesSemantic proximity Read ↗

Nanomaterials for reversion of multidrug resistance in cancer: a new hope for an old idea?Semantic proximity Read ↗

Nano-Based Drug Delivery and Targeting to Overcome Drug Resistance of Ovarian CancersSemantic proximity Read ↗

Inhibition of ABCB1 (MDR1) Expression by an siRNA Nanoparticulate Delivery System to Overcome Drug Resistance in OsteosarcomaSemantic proximity Read ↗

Microparticles induce multifactorial resistance through oncogenic pathways independently of cancer cell typeSemantic proximity Read ↗

Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancerSemantic proximity Read ↗

Targeting ABCB1 (MDR1) in multi-drug resistant osteosarcoma cells using the CRISPR-Cas9 system to reverse drug resistanceSemantic proximity Read ↗

miR-200c increases the sensitivity of breast cancer cells to Doxorubicin through downregulating MDR1 geneSemantic proximity Read ↗

Enhancing Breast Cancer Therapy: Nanocarrier-Based Targeted Drug DeliverySemantic proximity Read ↗

Microparticle-associated nucleic acids mediate trait dominance in cancer.Semantic proximity Read ↗

Enhanced cytotoxicity and nuclear accumulation of doxorubicin-loaded nanospheres in human breast cancer MCF7 cells expressing MRP1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.