Article
Genetic Mechanisms Involved in the Generation of HLA Alleles in Brazilians: Description and Comparison of HLA Alleles.
Transplantation proceedings - 1 Apr 2018
Fabreti-Oliveira R A, Lasmar M F, Oliveira C K F, Vale E M G, Nascimento E
Abstract excerpt
BACKGROUND: The HLA genes show high levels of diversity as indicated by the number of HLA alleles. There are almost 11,000 classical HLA-A, -B, -DRB1 alleles in populations around the world, making the search for compatible donors difficult. HLA diversity is generated by different genetic mechanisms, such as point mutations, which result in single nucleotide polymorphisms, insertion and deletion, and...
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