Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Seven novel HLA alleles reflect different mechanisms involved in the evolution of HLA diversity: description of the new alleles and review of the literature.

Human immunology - 1 Jan 2015

Adamek Martina, Klages Cornelia, Bauer Manuela, Kudlek Evelina, Drechsler Alina, Leuser Birte, Scherer Sabine, Opelz Gerhard, Tran Thuong Hien

Abstract excerpt

The human leukocyte antigen (HLA) loci are among the most polymorphic genes in the human genome. The diversity of these genes is thought to be generated by different mechanisms including point mutation, gene conversion and crossing-over. During routine HLA typing, we discovered seven novel HLA alleles which were probably generated by different evolutionary mechanisms. HLA-B*41:21, HLA-DQB1*02:10 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crossing Over, Genetic
Share to Gene Conversion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-A Antigens

Share to HLA-B Antigens

Share to HLA-C Antigens

Share to HLA-DQ alpha-Chains

Share to HLA-DQ beta-Chains

Share to Tissue Donors

Source

Identifiers

PMID: 25500251
DOI: 10.1016/j.humimm.2014.12.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Seven novel HLA alleles reflect different mechanisms involved in the evolution of HLA diversity: description of the new alleles and review of the literature.PMID 25500251Read ↗

Seventy-eight novel HLA class I and II alleles identified during routine registry typing in 2008 and 2009.Semantic proximity Read ↗

Seven Novel HLA Alleles, HLA-A*01:01:170, -A*03:537, -B*14:148, -B*38:134, -B*45:01:15, -C*02:261 and -C*04:575.Semantic proximity Read ↗

Genetic Mechanisms Involved in the Generation of HLA Alleles in Brazilians: Description and Comparison of HLA Alleles.Semantic proximity Read ↗

Novel HLA class I and II alleles identified during routine registry typing in 2010.Semantic proximity Read ↗

Expanding diversity at the HLA-B locus: 28 novel HLA-B alleles.Semantic proximity Read ↗

Characterization of 236 novel alleles at the HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 loci from China Marrow Donor Program.Semantic proximity Read ↗

Description of novel class I alleles encountered during routine registry typing in 2007.Semantic proximity Read ↗

Identification of 400 novel alleles at the HLA-A, -B, -C, -DRB1, -DQB1 loci from China Marrow Donor Program.Semantic proximity Read ↗

Three new HLA class I alleles with synonymous mutations: HLA-A*03:01:62, -C*07:02:82 and -C*12:03:42.Semantic proximity Read ↗

Thirty-six novel HLA alleles: 7 HLA-A, 11 HLA-B, 15 HLA-C and 3 HLA-DRB1.Semantic proximity Read ↗

Characterisation of a new HLA-B allele, HLA-B*0724.Semantic proximity Read ↗

Characterization of three novel HLA alleles with silent nucleotide substitutions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.