Article
Regulation of ATG8 membrane association by ATG4 in the parasitic protist Toxoplasma gondii.
Autophagy - 1 Sept 2013
Kong-Hap Marie A, Mouammine Annabelle, Daher Wassim, Berry Laurence, Lebrun Maryse, Dubremetz Jean-François, Besteiro Sébastien
Abstract excerpt
In the process of autophagy, the Atg8 protein is conjugated, through a ubiquitin-like system, to the lipid phosphatidylethanolamine (PE) to associate with the membrane of forming autophagosomes. There, it plays a crucial role in the genesis of these organelles and in autophagy in general. In most eukaryotes, the cysteine peptidase Atg4 processes the C terminus of cytosolic Atg8 to regulate its association with...
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