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Article

Akt, mTOR and NF-κB pathway activation in Treponema pallidum stimulates M1 macrophages.

International immunopharmacology - 1 Jun 2018

Lin Li-Rong, Gao Zheng-Xiang, Lin Yong, Zhu Xiao-Zhen, Liu Wei, Liu Dan, Gao Kun, Tong Man-Li, Zhang Hui-Lin, Liu Li-Li, Xiao Yao, Niu Jian-Jun, Liu Fan, Yang Tian-Ci

Abstract excerpt

The polarization of macrophages and the molecular mechanism involved during the early process of syphilis infection remain unknown. This study was conducted to explore the influence of Treponema pallidum (T. pallidum) treatment on macrophage polarization and the Akt-mTOR-NFκB signaling pathway mechanism involved in this process. M0 macrophages derived from the phorbol-12-myristate-13-acetate-induced human acute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29656208
DOI: 10.1016/j.intimp.2018.03.040

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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