Functional relevance of synonymous alleles reflected in allele rareness in the population.

doi:10.1016/j.ygeno.2018.04.003

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Article

Functional relevance of synonymous alleles reflected in allele rareness in the population.

Genomics - 1 Nov 2018

Im Eu-Hyun, Hahn Yoonsoo, Choi Sun Shim

Abstract excerpt

We provide theoretical evidence supporting the non-neutrality of synonymous alleles by investigating the rareness of synonymous alleles in the population. We find a significantly greater number of synonymous rare alleles than conventional neutral alleles derived from noncoding regions. A permutation experiment shows that the rareness of synonymous alleles is not a byproduct of random statistical noise. We then...

Topics

Evolution, Molecular
Gene Frequency
Genetics, Population
Humans
Models, Genetic
Polymorphism, Single Nucleotide
Silent Mutation

Source

Open in PubMed

Identifiers

PMID: 29655905
DOI: 10.1016/j.ygeno.2018.04.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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