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Article

Progression of urothelial carcinoma in situ of the urinary bladder: a switch from luminal to basal phenotype and related therapeutic implications.

Virchows Archiv : an international journal of pathology - 1 May 2018

Barth Isabella, Schneider Ursula, Grimm Tobias, Karl Alexander, Horst David, Gaisa Nadine T, Knüchel Ruth, Garczyk Stefan

Abstract excerpt

The stratification of bladder cancer into luminal and basal tumors has recently been introduced as a novel prognostic system in patient cohorts of muscle-invasive bladder cancer or high-grade papillary carcinomas. Using a representative immunohistochemistry panel, we analyzed luminal and basal marker expression in a large case series (n = 156) of urothelial carcinoma in situ (CIS), a precancerous lesion that...

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Source

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Identifiers

PMID: 29654370
DOI: 10.1007/s00428-018-2354-9
PMCID: PMC5978840

Genes

GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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