Article
Characterisation of OXA-258 enzymes and AxyABM efflux pump in Achromobacter ruhlandii.
Journal of global antimicrobial resistance - 1 Sept 2018
Papalia Mariana, Traglia Germán, Ruggiero Melina, Almuzara Marisa, Vay Carlos, Gutkind Gabriel, Ramírez María Soledad, Radice Marcela
Abstract excerpt
OBJECTIVES: The aim of this study was to characterise OXA-258 variants and other features that may contribute to carbapenem resistance in Achromobacter ruhlandii. METHODS: Kinetic parameters for purified OXA-258a and OXA-258b were determined measuring the rate of hydrolysis of a representative group of antimicrobial agents. Whole-genome shotgun sequencing was performed on A. ruhlandii 38 (producing OXA-258a) and...
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