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Dynamics of Simian Immunodeficiency Virus Two-Long-Terminal-Repeat Circles in the Presence and Absence of CD8+Cells

11 Apr 2018

Abstract excerpt

ABSTRACT CD8+cells play a key role in human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection, but their specific mechanism(s) of action in controlling the virus is unclear. Two-long-terminal-repeat (2-LTR) circles are extrachromosomal products generated upon failed integration of HIV/SIV. To understand the specific effects of CD8+cells on infected cells, we analyzed the dynamics of 2-LTR...

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PMID: 29643246
DOI: 10.1128/jvi.02100-17

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