Article
Sex-specific aspects of phospholamban cardiomyopathy: The importance and prognostic value of low-voltage electrocardiograms.
Heart rhythm - 1 Mar 2022
de Brouwer Remco, Meems Laura M G, Verstraelen Tom E, Mahmoud Belend, Proost Virginnio, Wilde Arthur A M, Bosman Laurens P, van Drie Esmée, van der Zwaag Paul A, van Tintelen J Peter, Houweling Arjan C, van den Berg Maarten P, de Boer Rudolf A
Abstract excerpt
BACKGROUND: A pathogenic variant in the gene encoding phospholamban (PLN), a protein that regulates calcium homeostasis of cardiomyocytes, causes PLN cardiomyopathy. It is characterized by a high arrhythmic burden and can progress to severe cardiomyopathy. Risk assessment guides implantable cardioverter-defibrillator therapy and benefits from personalization. Whether sex-specific differences in PLN cardiomyopathy...
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