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Article

The phenotypic characteristic observed by cardiac magnetic resonance in a PLN-R14del family.

Scientific reports - 5 Oct 2020

Jiang Xincheng, Xu Yuanwei, Sun Jiayu, Wang Lili, Guo Xinli, Chen Yucheng

Abstract excerpt

Phospholamban (PLN) is an important regulator for sarcoendoplasmic reticulum (SR) calcium transport ATPase (SERCA), which uptakes Ca2+ to SR during the diastolic phase of cardiomyocytes to maintain intracellular calcium homeostasis. Mutations on PLN result in intracellular calcium disorder, myocardial contraction defect, and eventually heart failure and/or malignant ventricular arrhythmia. Since 2003, several...

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Identifiers

PMID: 33020536
DOI: 10.1038/s41598-020-73359-8
PMCID: PMC7536202

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