Article
The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2012
Godel Christelle, Kumar Sujai, Koutsovoulos Georgios, Ludin Philipp, Nilsson Daniel, Comandatore Francesco, Wrobel Nicola, Thompson Marian, Schmid Christoph D, Goto Susumu, Bringaud Frédéric, Wolstenholme Adrian, Bandi Claudio, Epe Christian, Kaminsky Ronald, Blaxter Mark, Mäser Pascal
Abstract excerpt
The heartworm Dirofilaria immitis is an important parasite of dogs. Transmitted by mosquitoes in warmer climatic zones, it is spreading across southern Europe and the Americas at an alarming pace. There is no vaccine, and chemotherapy is prone to complications. To learn more about this parasite, we have sequenced the genomes of D. immitis and its endosymbiont Wolbachia. We predict 10,179 protein coding genes in...
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