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Article

Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas.

Cell reports - 3 Apr 2018

Meghani Khyati, Fuchs Walker, Detappe Alexandre, Drané Pascal, Gogola Ewa, Rottenberg Sven, Jonkers Jos, Matulonis Ursula, Swisher Elizabeth M, Konstantinopoulos Panagiotis A, Chowdhury Dipanjan

Abstract excerpt

BRCA1/2-mutated ovarian cancers (OCs) are defective in homologous recombination repair (HRR) of double-strand breaks (DSBs) and thereby sensitive to platinum and PARP inhibitors (PARPis). Multiple PARPis have recently received US Food and Drug Administration (FDA) approval for treatment of OCs, and resistance to PARPis is a major clinical problem. Utilizing primary and recurrent BRCA1/2-mutated carcinomas from OC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29617652
DOI: 10.1016/j.celrep.2018.03.038
PMCID: PMC5908239

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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