Article
High-throughput full-length single-cell mRNA-seq of rare cells.
PloS one - 1 Jan 2017
Ooi Chin Chun, Mantalas Gary L, Koh Winston, Neff Norma F, Fuchigami Teruaki, Wong Dawson J, Wilson Robert J, Park Seung-Min, Gambhir Sanjiv S, Quake Stephen R, Wang Shan X
Abstract excerpt
Single-cell characterization techniques, such as mRNA-seq, have been applied to a diverse range of applications in cancer biology, yielding great insight into mechanisms leading to therapy resistance and tumor clonality. While single-cell techniques can yield a wealth of information, a common bottleneck is the lack of throughput, with many current processing methods being limited to the analysis of small volumes...
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