Article
Cigarette smoke exposure promotes differentiation of CD4+ T cells toward Th17 cells by CD40-CD40L costimulatory pathway in mice.
International journal of chronic obstructive pulmonary disease - 1 Jan 2018
Liang Yi, Shen Ying, Kuang Liangjian, Zhou Guang, Zhang Longju, Zhong Xiaoning, Zhang Jianquan, Liu Jifeng
Abstract excerpt
Purpose: This study aimed to investigate the impact of cigarette smoke exposure upon CD40-CD40L ligation between bone marrow-derived dendritic cells (BMDCs)and CD4+T cells, and to examine the effects of cigarette smoke exposure upon differentiation of CD4+T cells toward Th17 cells through blockade of CD40-CD40L pathway in mice. Methods: The study was processed in vivo and in vitro. In vivo, Th17 cells, CD40,...
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