Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2016

Inaba Yasuko, Shinohara Kyosuke, Botilde Yanick, Nabeshima Ryo, Takaoka Katsuyoshi, Ajima Rieko, Lamri Lynda, Takeda Hiroyuki, Saga Yumiko, Nakamura Tetsuya, Hamada Hiroshi

Abstract excerpt

Lrrc6 encodes a cytoplasmic protein that is expressed specifically in cells with motile cilia including the node, trachea and testes of the mice. A mutation of Lrrc6 has been identified in human patients with primary ciliary dyskinesia (PCD). Mutant mice lacking Lrrc6 show typical PCD defects such as hydrocephalus and laterality defects. We found that in the absence of Lrrc6, the morphology of motile cilia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axonemal Dyneins
Share to Axoneme

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Cytoskeletal Proteins

Share to Dyneins

Share to Kartagener Syndrome

Share to Proteins

Source

Identifiers

PMID: 27353389
DOI: 10.1111/gtc.12380

Genes

DNAH5
DNAH9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6.PMID 27353389Read ↗

Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects.Semantic proximity Read ↗

Loss-of-function mutations in LRRC6, a gene essential for proper axonemal assembly of inner and outer dynein arms, cause primary ciliary dyskinesia.Semantic proximity Read ↗

ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.Semantic proximity Read ↗

LRRC56 deletion causes primary ciliary dyskinesia in mice characterized by dynein arms defectsSemantic proximity Read ↗

LRRC6 Mutation Causes Primary Ciliary Dyskinesia with Dynein Arm DefectsSemantic proximity Read ↗

Physical and functional interaction of Lrrc56 and Odad3 controls deployment of axonemal dyneins in vertebrate multiciliated cellsSemantic proximity Read ↗

Strongly truncated <i>Dnaaf4</i> plays a conserved role in <i>Drosophila</i> ciliary dynein assembly as part of an R2TP-like co-chaperone complex with <i>Dnaaf6</i>Semantic proximity Read ↗

ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6.Semantic proximity Read ↗

A novel homozygous LRRC6 mutation causes male infertility with asthenozoospermia and primary ciliary dyskinesia in humans.Semantic proximity Read ↗

Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility.Semantic proximity Read ↗

CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs.Semantic proximity Read ↗

Biallelic Mutations in <i>LRRC56</i> encoding a protein associated with intraflagellar transport, cause mucociliary clearance and laterality defectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.