Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score

Abstract excerpt

BACKGROUND: Since 1946 the controlled human infection model (CHIM) for Shigella has been used to improve understanding of disease pathogenesis, describe clinical and immunologic responses to infection and as a tool for vaccine development. As the frequency and intent for use in vaccine comparisons increases, standardization of the primary endpoint definition is necessary. METHODS: Subject-level data were obtained...

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