MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis.

doi:10.1186/s12881-018-0565-1

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Article

MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis.

BMC medical genetics - 27 Mar 2018

Maharaj Ajesh B, Naidoo Pragalathan, Ghazi Terisha, Abdul Naeem S, Dhani Shanel, Docrat Taskeen F, Ramkaran Prithiksha, Tak Paul-Peter, de Vries Niek, Chuturgoon Anil A

Abstract excerpt

BACKGROUND: Psoriasis and psoriatic arthritis (PsA) are inflammatory associated autoimmune disorders. MicroRNA (miR)-146a plays a crucial role in regulating inflammation. A single nucleotide polymorphism in the miR-146a gene (rs2910164), aberrantly alters its gene expression and linked with the pathogenesis of several disorders, including psoriasis and PsA. In South Africa, psoriasis and PsA are extremely rare in...

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PMID: 29587639
DOI: 10.1186/s12881-018-0565-1
PMCID: PMC5870474

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