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Article

Lifelong calorie restriction affects indicators of colonic health in aging C57Bl/6J mice.

The Journal of nutritional biochemistry - 1 Jun 2018

Kok Dieuwertje E G, Rusli Fenni, van der Lugt Benthe, Lute Carolien, Laghi Luca, Salvioli Stefano, Picone Gianfranco, Franceschi Claudio, Smidt Hauke, Vervoort Jacques, Kampman Ellen, Müller Michael, Steegenga Wilma T

Abstract excerpt

Diminished colonic health is associated with various age-related pathologies. Calorie restriction (CR) is an effective strategy to increase healthy lifespan, although underlying mechanisms are not fully elucidated. Here, we report the effects of lifelong CR on indicators of colonic health in aging C57Bl/6J mice. Compared to an ad libitum control and moderate-fat diet, 30% energy reduction was associated with...

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Identifiers

PMID: 29571009
DOI: 10.1016/j.jnutbio.2018.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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