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Article

High dietary protein and fat contents exacerbate hepatic senescence and SASP in mice.

The FEBS journal - 1 Mar 2023

Nehme Jamil, Yang Dengbao, Altulea Abdullah, Varela-Eirin Marta, Wang Lu, Hu Sumei, Wu Yingga, Togo Jacques, Niu Chaoqun, Speakman John R, Demaria Marco

Abstract excerpt

Dietary choices have a profound impact on the aging process. In addition to the total amount of energy intake, macronutrient composition influences both health and lifespan. However, the exact mechanisms by which dietary macronutrients influence onset and progression of age-associated features remain poorly understood. Cellular senescence is a state of stable growth arrest characterized by the secretion of...

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PMID: 34908245
DOI: 10.1111/febs.16292

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