Article
Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond-Forming Oxidoreductase A-Like Protein (DsbA-L) Polymorphism on the Weight Status.
CPT: pharmacometrics & systems pharmacology - 1 Jun 2018
Oniki Kentaro, Watanabe Takehisa, Kudo Miku, Izuka Tomoko, Ono Tatsumasa, Matsuda Kazuki, Sakamoto Yuki, Nagaoka Katsuya, Imafuku Tadashi, Ishima Yu, Watanabe Hiroshi, Maruyama Toru, Otake Koji, Ogata Yasuhiro, Saruwatari Junji
Abstract excerpt
Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity. Disulfide bond-forming oxidoreductase A-like protein (DsbA-L) is known to be a key molecule in protection against obesity and obesity-induced inflammation. In the present study, we used a modeling and simulation approach in an attempt to develop body mass index (BMI) and BMI-based NAFLD prediction models incorporating the DsbA-L...
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