Gut-microbiome-related LCT genotype and 2-year changes in body composition and fat distribution: the POUNDS Lost Trial.

doi:10.1038/s41366-018-0046-9

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Gut-microbiome-related LCT genotype and 2-year changes in body composition and fat distribution: the POUNDS Lost Trial.

International journal of obesity (2005) - 1 Sept 2018

Heianza Yoriko, Sun Dianjianyi, Ma Wenjie, Zheng Yan, Champagne Catherine M, Bray George A, Sacks Frank M, Qi Lu

Abstract excerpt

BACKGROUND/OBJECTIVES: Gut microbiome regulates host energy metabolism and adiposity. A recent study identified a genome-wide significant variant in the lactase (LCT) gene that determines gut-microbiome abundance. We investigated whether the LCT variant influenced long-term changes in adiposity among overweight and obese individuals. SUBJECTS/METHODS: We included 583 whites with LCT variant rs4988235 (G allele as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiposity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bacterial Proteins

Share to Bifidobacterium

Share to Body Composition

Share to Diet, Protein-Restricted

Share to Gastrointestinal Microbiome

Share to Lactase

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 29568104
DOI: 10.1038/s41366-018-0046-9
PMCID: PMC6109621

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gut-microbiome-related LCT genotype and 2-year changes in body composition and fat distribution: the POUNDS Lost Trial.PMID 29568104Read ↗

Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes.Semantic proximity Read ↗

Large-scale searching for causal relationships of milk consumption with multi-omics and disease susceptibility: A phenome-wide Mendelian randomization study.Semantic proximity Read ↗

Large-scale association analyses identify host factors influencing human gut microbiome composition.Semantic proximity Read ↗

Large-scale association analyses identify host factors influencing human gut microbiome compositionSemantic proximity Read ↗

Toward Precision Weight-Loss Dietary Interventions: Findings from the POUNDS Lost TrialSemantic proximity Read ↗

Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene on Changes in Serum Lipid Concentrations during a Long-Term Weight-Loss Intervention Trial.Semantic proximity Read ↗

Recent advances in understanding the adaptive evolution of metabolic genes and traits.Semantic proximity Read ↗

TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention.Semantic proximity Read ↗

Genetic variation in lean body mass, changes of appetite and weight loss in response to diet interventions: The POUNDS Lost trial.Semantic proximity Read ↗

Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial.Semantic proximity Read ↗

Macronutrient Intake-Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial.Semantic proximity Read ↗

Starch Digestion-Related Amylase Genetic Variants, Diet, and Changes in Adiposity: Analyses in Prospective Cohort Studies and a Randomized Dietary Intervention.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.