Article
Site-Specific Fat-1 Knock-In Enables Significant Decrease of n-6PUFAs/n-3PUFAs Ratio in Pigs.
G3 (Bethesda, Md.) - 4 May 2018
Li Mengjing, Ouyang Hongsheng, Yuan Hongming, Li Jianing, Xie Zicong, Wang Kankan, Yu Tingting, Liu Minghao, Chen Xue, Tang Xiaochun, Jiao Huping, Pang Daxin
Abstract excerpt
The fat-1 gene from Caenorhabditis elegans encodes a fatty acid desaturase which was widely studied due to its beneficial function of converting n-6 polyunsaturated fatty acids (n-6PUFAs) to n-3 polyunsaturated fatty acids (n-3PUFAs). To date, many fat-1 transgenic animals have been generated to study disease pathogenesis or improve meat quality. However, all of them were generated using a random integration...
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