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Whole genome sequencing reveals novel genetic mutations of Helicobacter pylori associating with resistance to clarithromycin and levofloxacin.

Helicobacter - 1 Aug 2023

Lyu Tao, Cheung Ka Shing, Deng Zijie, Ni Li, Chen Chuan, Wu Juan, Leung Wai K, Seto Wai Kay

Abstract excerpt

BACKGROUND: Detection of mutations in one or a couple of genes may not provide enough data or cover all the genomic DNA variance related to antibiotic resistance of Helicobacter pylori to clarithromycin (CLA) and levofloxacin (LVX). We aimed to perform whole genome sequencing to explore novel antibiotic resistance-related genes to increase predictive accuracy for future targeted sequencing tests. METHODS: Gastric...

Topics

Humans
Male
Adult
Female
Clarithromycin
Levofloxacin
Helicobacter pylori
Helicobacter Infections
Drug Resistance, Bacterial
Microbial Sensitivity Tests
Anti-Bacterial Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Whole Genome Sequencing

RNA, Ribosomal, 23S

Source

Identifiers

PMID: 36965192
DOI: 10.1111/hel.12972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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