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Article

Loss of Parkin impairs mitochondrial function and leads to muscle atrophy

21 Mar 2018

Abstract excerpt

Parkinson's disease is a neurodegenerative disease characterized by tremors, muscle stiffness, and muscle weakness. Molecular genetic analysis has confirmed that mutations in PARKIN and PINK1 genes, which play major roles in mitochondrial quality control and mitophagy, are frequently associated with Parkinson's disease. PARKIN is an E3 ubiquitin ligase that translocates to mitochondria during loss of...

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PMID: 29561660
DOI: 10.1152/ajpcell.00064.2017

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